Hydroxychloroquine blood levels in stable lupus nephritis under low dose (2-3 mg/kg/day): 12-month prospective randomized controlled trial.

Caio B ZanettiTatiana PedrosaLéonard de V K KupaNadia E AikawaEduardo F BorbaMargarete B G VendraminiClovis A SilvaSandra G PasotoEloisa S Bonfa

Published in: Clinical rheumatology (2021)

ClinicalTrials.gov : NCT03122431, registered on April 20, 2017 Key Points • Reduced American Academy of Ophthalmology (2016-AAO) hydroxychloroquine (HCQ) dose (2-3 mg/kg/day, real body weight) is unable to sustain HCQ blood levels within the safe cut-off defined for flare risk. • Full 2016-AAO dose (5 mg/kg/day) maintains a safe pattern of HCQ levels up to 12 months.

Keyphrases

body weight
randomized controlled trial
low dose
study protocol
high dose
meta analyses