Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype.
Jesús Beltrán-GarcíaRebeca Osca-VerdegalDaniel Pérez-CremadesSusana NovellaCarlos HermenegildoFederico V PallardóJosé Luis García-GiménezPublished in: Journal of inflammation research (2022)
Circulating histone levels correlated with the expression of pro-inflammatory and pyroptosis-related cytokines, the release of endothelial adhesion factors and septic shock severity. We propose to block histone-mediated pyroptosis as a feasible therapeutic strategy in sepsis.