Synthesis, radiosynthesis and in vitro evaluation of 18F-Bodipy-C16/triglyceride as a dual modal imaging agent for brown adipose tissue.

Andreas PaulusMarco MaenenNatascha DrudeEmmani B M NascimentoWouter D van Marken LichtenbeltFelix M MottaghyMatthias Bauwens

Published in: PloS one (2017)

The new developed dual modal fatty acid based tracers Bodipy-C16 and Bodipy-triglyceride showed promising results to stimulate further in vivo evaluation and will help to understand brown adipose tissues role in whole body energy expenditure.

Keyphrases

fluorescent probe
adipose tissue
living cells
fatty acid
insulin resistance
high resolution
high fat diet
gene expression
pet imaging
low density lipoprotein
mass spectrometry
photodynamic therapy