Pre- and Postnatal Maturation are Important for Fentanyl Exposure in Preterm and Term Newborns: A Pooled Population Pharmacokinetic Study.

Yunjiao WuSwantje VöllerRobert B FlintSinno H P SimonsKarel AllegaertVineta FellmanCatherijne A J Knibbe

Published in: Clinical pharmacokinetics (2021)

As both prenatal and postnatal maturation are important for fentanyl exposure, we propose a birthweight- and PNA-based dosage regimen. To provide rapid analgesia in the first 24 h of treatment, additional loading doses need to be considered.

Keyphrases

gestational age
preterm infants
low birth weight
pregnant women
preterm birth
pain management
ultrasound guided
randomized controlled trial
chronic pain
open label
sensitive detection
smoking cessation