Evaluation of [18F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy.

Sanni TuominenThomas KellerNataliia PetrukFrancisco López-PicónDominik EichinEliisa LöyttyniemiAlejandra VerhasselJohan RajanderJouko SandholmJohanna TuomelaTove J Grönroos

Published in: European journal of nuclear medicine and molecular imaging (2020)

[18F]F-DPA can detect changes in TSPO expression levels after RT in HNSCC, which does not seem to reflect inflammation. Further studies are however needed to clarify the physiological mechanisms regulated by TSPO after RT.

Keyphrases

pet imaging
poor prognosis
oxidative stress
early stage
radiation therapy
locally advanced
radiation induced
squamous cell carcinoma
binding protein
positron emission tomography
computed tomography
rectal cancer
pet ct