Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP).
Alexis TabahMatteo BassettiMarin H KollefJean-Ralph ZaharJosé-Artur PaivaJean-Francois TimsitJason A RobertsJeroen A SchoutenHelen GiamarellouJordi RelloJan J De WaeleAndrew F ShorrMarc LeoneGaryphallia PoulakouPieter DepuydtJose Garnacho-MonteroPublished in: Intensive care medicine (2019)
ADE remains a topic of controversy due to the complexity of clinical scenarios where it may be applied and the absence of evidence to the effects it may have on antimicrobial resistance.