Epigenetic modulation of FOXM1-gene interacting network by BET inhibitors in breast cancer.

Javier Pérez-PeñaBalázs GyőrffyEitan AmirAtanasio PandiellaAlberto Ocaña

Published in: Breast cancer research and treatment (2018)

Our study demonstrates that activation of the FOXM1 pathway has a prognostic role in breast cancer. JQ1 can modulate the expression of the FOXM1-gene interacting network, opening the opportunity for the evaluation of this compound in breast cancer patients.

Keyphrases

genome wide
copy number
poor prognosis
dna methylation
genome wide identification
protein kinase
gene expression
binding protein
transcription factor
long non coding rna
network analysis