Systematic review with meta-analysis: endoscopic and histologic placebo rates in induction and maintenance trials of ulcerative colitis.
Christopher MaLeonardo GuizzettiR PanaccioneRichard N FedorakRish K PaiC E ParkerT M NguyenR KhannaNiels Vande CasteeleGeert R A M D'HaensWilliam J SandbornBrian G FeaganVipul JairathPublished in: Alimentary pharmacology & therapeutics (2018)
Placebo endoscopic and histologic rates range from 14% to 35% in UC RCTs but are highly heterogeneous. Outcome standardisation may reduce heterogeneity and is needed in this field.