Prospective evaluation of treatment response and disease reversibility of paediatric localized scleroderma (morphoea) to steroids and methotrexate using multi-modal imaging.
L WeibelMartin TheilerK J HowellC P DentonR WaelchliD AthertonP WooJ I HarperPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)
Corticosteroids and methotrexate are highly effective as first-line therapy in paediatric localized scleroderma, leading to partial reversal of skin manifestations. However, the recurrence rate is substantial and affected children require long-term follow-up. Laser Doppler flowmetry and high-frequency ultrasound correlate with disease activity in the acute phase and may assist decision-making in these patients.
Keyphrases
- high frequency
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- systemic sclerosis
- transcranial magnetic stimulation
- intensive care unit
- end stage renal disease
- emergency department
- rheumatoid arthritis patients
- high dose
- ankylosing spondylitis
- ejection fraction
- newly diagnosed
- magnetic resonance imaging
- chronic kidney disease
- interstitial lung disease
- high resolution
- prognostic factors
- juvenile idiopathic arthritis
- patient reported outcomes
- mass spectrometry
- bone marrow
- free survival
- high speed
- smoking cessation
- cell therapy
- idiopathic pulmonary fibrosis
- contrast enhanced ultrasound