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Abnormal brain diffusivity in participants with persistent neuropsychiatric symptoms after COVID-19.

Huajun LiangThomas ErnstKenichi OishiMeghann C RyanEdward HerskovitsEric CunninghamEleanor WilsonShyamasundaran KottililLinda Chang
Published in: NeuroImmune pharmacology and therapeutics (2023)
Microstructural abnormalities are evident in PCC participants averaged six months after COVID-19. The restricted diffusivity (with reduced MD) and higher FA suggest enhanced myelination or increased magnetic susceptibility from iron deposition, as seen in stress conditions. The higher amygdala-MD in female PCC suggests persistent neuroinflammation, which might contribute to their fatigue, anxiety, and perceived stress.
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