Hepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation.

Liangjun Zhang Pingfan Xie Mingqiao Li Xiaoxun Zhang Shuke Fei Nan Zhao Ling Li Ziqian Xu Wan Tang Guanyu Zhu Zhixian Zhu Zuzhi Xu Jian-Wei Li Chengcheng Zhang James L BoyerWensheng ChenShi-Ying Cai Qiong Pan Jin Chai

Published in: Hepatology (Baltimore, Md.) (2024)

Elevated hepatic SLC35C1 expression attenuates cholestatic liver injury by enhancing CEACAM1 fucosylation to suppress CCL2 and CXCL2 expression and liver inflammation.

Keyphrases

liver injury
drug induced
poor prognosis
oxidative stress
binding protein
liver fibrosis
long non coding rna