Tau induces inflammasome activation and microgliosis through acetylating NLRP3.
Lun ZhangYongkang GaiYushuang LiuDongli MengYi ZengYong LuoHuiliang ZhangZhuoqun WangMengzhe YangYunfan LiYi LiuYiwen LaiJiayu YangGang WuYu ChenJingtan ZhuShaojun LiuTingting YuJi ZengJianzhi WangDan ZhuXiao-Chuan WangXiaoli LanRong LiuPublished in: Clinical and translational medicine (2024)
In conclusion, our findings provide evidence for a novel role of Tau in the regulation of microglia activation through acetylating NLRP3, which has potential implications for early intervention and personalised treatment of AD and related Tauopathies.