Matching Imaging and Remodulation Effects: Benefits of Cardiac Contractility Modulation Shown by Global Longitudinal Strain: A Case Report.
Andrea MatteucciGiacomo BonacchiVincenzo Mirco La FaziaGiuseppe StifanoDomenico SergiPublished in: Clinics and practice (2022)
Cardiac Contractility Modulation (CCM) has been proposed for inpatients affected by heart failure with reduced ejection fraction (HFrEF), with relapsing HF symptoms. We present a case of a patient treated with percutaneous coronary intervention (PCI) in the setting of acute coronary syndrome without persistent ST-segment elevation, with the best medical therapy for decompensated HF. The patient refused the implantable cardioverter-defibrillator (ICD), and to reduce the increasing number of hospitalizations for HF exacerbations, we proposed the use of the cardiac contractility modulation device. After the implant, the patient demonstrated a marked improvement in exercise effort and quality of life (QOL) with a six-minute walk test (SMWT), Minnesota Living with Heart Failure Questionnaire (MLWHFQ), and echocardiographic parameters. At 9 months after discharge, no hospital admissions for HF were recorded. We showed with the speckle tracking imaging how the improvement in global longitudinal strain (GLS) correlates with the remodeling effects on myocardial cells.
Keyphrases
- heart failure
- left ventricular
- acute coronary syndrome
- percutaneous coronary intervention
- acute heart failure
- acute myocardial infarction
- case report
- antiplatelet therapy
- high resolution
- coronary artery disease
- st segment elevation myocardial infarction
- atrial fibrillation
- cardiac resynchronization therapy
- multiple sclerosis
- st elevation myocardial infarction
- smooth muscle
- induced apoptosis
- cross sectional
- healthcare
- chronic obstructive pulmonary disease
- mitral valve
- pulmonary hypertension
- cystic fibrosis
- left atrial
- high intensity
- endoplasmic reticulum stress
- newly diagnosed
- mass spectrometry
- rheumatoid arthritis
- disease activity
- depressive symptoms
- cell cycle arrest
- photodynamic therapy