Line-probe assay and molecular typing reveal a potential drug resistant clone of Mycobacterium tuberculosis in Ethiopia.
Shiferaw BekeleYohannes DereseElena HailuAdane MihretKifle DagneLawrence YamuahTsegaye HailuSamuel AyeleDemissew BeyeneStefan BergAbraham AseffaPublished in: Tropical diseases, travel medicine and vaccines (2018)
Although the strain selection was not fully randomized, the overall M. tuberculosis drug resistance rate in this strain set was 8.7% while the rate of MDR was 3.1%. In parallel, we identified a sub-lineage that showed a high rate of resistance to both rifampicin and isoniazid. These resistant strains may belong to a clone of M. tuberculosis that is circulating in the highlands of Ethiopia.
Keyphrases
- mycobacterium tuberculosis
- drug resistant
- multidrug resistant
- pulmonary tuberculosis
- acinetobacter baumannii
- single cell
- double blind
- escherichia coli
- open label
- high throughput
- placebo controlled
- phase iii
- phase ii
- gene expression
- single molecule
- emergency department
- risk assessment
- randomized controlled trial
- hiv infected
- dna methylation
- study protocol