Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study.
Emily W PaolilloKaitlin B CasalettoAnnie L ClarkJack Carson TaylorHilary W HeuerAmy B WiseSreya DhanamMark Sanderson-CiminoRowan SalonerJoel H KramerJohn KornakWalter K KremersLeah K ForsbergBrian S ApplebyEce BayramAndrea BozokiDanielle BrushaberRichard Ryan DarbyGregory S DayBradford C DickersonKimiko Domoto-ReillyFanny M ElahiJulie A FieldsNupur GhoshalNeill R Graff-RadfordMatthew G H HallLawrence S HonigEdward D HueyMaria I LapidIrene LitvanIan R A MackenzieJoseph C MasdeuMario F MendezCarly T MesterToji MiyagawaGeorges NaasanMaria B PascualPeter S PressmanEliana Marisa RamosKatherine P RankinJessica E RexachJulio C RojasLawren VandeVredeBonnie WongZbigniew K WszolekBradley F BoeveHoward J RosenAdam L BoxerAdam M Staffaroninull nullPublished in: JMIR aging (2024)
These findings support a proof of concept that passively collected data about smartphone use behaviors associate with clinical impairment in FTLD. This work underscores the need for future studies to develop and validate passive digital markers sensitive to longitudinal clinical decline across neurodegenerative diseases, with potential to enhance real-world monitoring of neurobehavioral change.