Longitudinal Assessment of Creatine Kinase, Creatine/Creatinine ratio , and Myostatin as Monitoring Biomarkers in Becker Muscular Dystrophy.
Nienke M van de VeldeZaïda KoeksMirko SignorelliNisha VerweyMaurice OverzierJaap Adriaan BakkerGautam SajeevJames SignorovitchValeria RicottiJan J G M VerschuurenKristy BrownPietro SpitaliErik H NiksPublished in: Neurology (2022)
Both Cr/Crn and myostatin could potentially serve as monitoring biomarkers in BMD, as higher Cr/Crn and lower myostatin were associated with lower motor performance and predictive of concurrent functional performance when combined with age. Future studies are needed to more precisely determine the context of use of these biomarkers.