Obesity and Roux-en-Y gastric bypass drive changes in miR-31 and miR-215 expression in the human rectal mucosa.

Stella Panagio BreiningerLaura SabaterFiona Caroline MalcomsonSorena AfsharJelena MannJohn Cummings Mathers

Published in: International journal of obesity (2005) (2021)

Our findings show, for the first time, that obesity is associated with dysregulated microRNA expression in the human rectal mucosa. Further, surgically-induced weight loss may normalise microRNA expression in this tissue.

Keyphrases

weight loss
roux en y gastric bypass
poor prognosis
long non coding rna
bariatric surgery
endothelial cells
gastric bypass
cell proliferation
insulin resistance
metabolic syndrome
type diabetes
obese patients
rectal cancer
induced pluripotent stem cells
high fat diet induced
glycemic control
diabetic rats