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Integration of immunohistochemistry, RNA sequencing, and multiplex ligation-dependent probe amplification for molecular classification of pediatric medulloblastoma.

Hsin-Yi HuangChih-Hsiang YuYung-Li YangYa-Hsuan ChangShiann-Tarng JouKai-Hsin LinMeng-Yao LuHsiu-Hao ChangShu-Wei ChouYu-Ling NiDong-Tsamn LinHsuan-Yu ChenSteven Shinn-Forng PengMeng-Fai KuoShih-Hung Yang
Published in: Pediatric blood & cancer (2022)
Our study revealed that integration of these diagnostic tools can provide a precise and timely classification of MB, optimizing an individualized, risk-directed postoperative adjuvant therapy for these patients. This workflow can be applied in a countrywide fashion to guide future clinical trials for patients with MB.
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