Notch signaling and progenitor/ductular reaction in steatohepatitis.

Carola M MorellRomina FiorottoMarica MeroniAileen RaiznerBarbara TorselloMassimiliano CadamuroGaia SpagnuoloEleanna KaffeSalvatore SuttiEmanuele AlbanoMario Strazzabosco

Published in: PloS one (2017)

Our data suggest that Notch signaling is an important regulator of DR and that in steatohepatitis, hepatocytes exposed to Jag1-positive HSC, contribute to pathologic DR by undergoing Notch-mediated differentiation towards an HPC-like phenotype. Given the roles of Notch in fibrosis and liver cancer, these data suggest mesenchymal expression of Jag1 as an alternative therapeutic target.

Keyphrases

electronic health record
big data
cell proliferation
poor prognosis
editorial comment
stem cells
bone marrow
transcription factor
machine learning
squamous cell carcinoma
data analysis
radiation therapy
liver injury
artificial intelligence
locally advanced