Efficacy and safety of calcium channel blockers in preventing cardiac siderosis in thalassemia patients: An updated meta-analysis with trial sequential analysis.

Youssef SolimanAhmed AbdelazizAdel MouffokesBasma E AmerYomna Mohamed GoudyOmar Ahmed AbdelwahabMarwa M BadawyRehab Adel DiabAsmaa Elsharkawy

Published in: European journal of haematology (2023)

Our meta-analysis found that amlodipine significantly increases cardiac T2* and decreases MIC, hence decreasing the incidence of cardiomyopathy-related iron overload in thalassemia patients.

Keyphrases

systematic review
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
heart failure
prognostic factors
left ventricular
clinical trial
randomized controlled trial
meta analyses
risk factors
study protocol
patient reported outcomes
sickle cell disease
angiotensin ii
case control