Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin.

Yuki TanakaShin KadotaJian ZhaoHideki KobayashiSatomi OkanoMasaki IzumiYusuke HondaHajime IchimuraNaoko ShibaTakeshi UemuraYuko WadaShinichiro ChumaTsutomu NakadaShugo TohyamaKeiichi FukudaMitsuhiko YamadaTatsuichiro SetoKoichiro KuwaharaYuji Shiba

Published in: Stem cell research & therapy (2023)

Long-term cultured mature hiPSC-CMs promoted engraftment, maturation and angiogenesis post-transplantation in infarcted rat hearts. CRYAB, which was highly expressed in D56-CMs, was identified as an angiogenic factor from mature hiPSC-CMs. This study revealed the benefits of long-term culture, which may enhance the therapeutic potential of hiPSC-CMs.

Keyphrases

endothelial cells
high glucose
vascular endothelial growth factor
oxidative stress
single cell
stem cells
cell therapy
wound healing
drug induced
pluripotent stem cells