Early diagnosis, disease stage and prognosis in wild-type transthyretin amyloid cardiomyopathy: The DIAMOND study.
Giacomo TiniBeatrice MusumeciPaolo MilaniMattia ZampieriAngelo Giuseppe CaponettiFrancesca FabrisAndrea FoliAlessia ArgiròCarlotta MazzoniChristian GagliardiSimone LonghiGiulia SaturiGiuseppe VergaroAlberto AimoLudovica De FazioGuerino Giuseppe VarràMatteo SerenelliGioele FabbriLaura De MichieliGiuseppe PalmieroGiuseppe CilibertiSamuela CarigiMargherita ZanolettiGiulia Elena MandoliGiulia Ricci LucchiValeria RellaEnrico MontiElisa GardiniMichela BartolottiLia CrottiElisa MerliRoberta MussinelliPier Filippo VianelloMatteo CameliFrancesca MarzoFederico GuerraGiuseppe LimongelliAlberto CiprianiStefano PerliniLaura ObiciFederico PerfettoEmanuele BarbatoItalo PortoGianfranco SinagraMarco MerloMichele EmdinElena BiaginiFrancesco CappelliGiovanni PalladiniMarco CanepaPublished in: ESC heart failure (2024)
In this contemporary nationwide cohort, an ATTRwt-CA early diagnosis was very rare. Disease staging with NAC and Columbia scoring systems determined classes of patients with heterogeneous features. Both scores were significantly associated with mortality, but other variables also had prognostic significance.