Oral intake of lipopolysaccharide regulates toll-like receptor 4-dependent granulopoiesis.
Melanie MärklinStefanie BuglStefan WirthsJulia-Stefanie FrickMartin R MüllerHans-Georg KoppDominik SchneidawindPublished in: Experimental biology and medicine (Maywood, N.J.) (2020)
In our present study, we investigated the impact of LPS on neutrophil homeostasis and found that oral intake is sufficient to induce hematopoietic stem and progenitor cell fate decisions towards the neutrophil lineage independent of G-CSF. In addition, TLR4 has been identified as the indispensable sensor for oral LPS-modulated steady-state granulopoiesis. We provide evidence that the gastrointestinal microbiome is critical for neutrophil homeostasis, which has implications for patients being treated with chemotherapy or antimicrobial therapy, since both are significantly influencing the composition of the intestinal microbiome.
Keyphrases
- toll like receptor
- inflammatory response
- nuclear factor
- immune response
- newly diagnosed
- lps induced
- end stage renal disease
- ejection fraction
- staphylococcus aureus
- prognostic factors
- anti inflammatory
- physical activity
- weight gain
- mass spectrometry
- bone marrow
- radiation therapy
- weight loss
- body mass index
- cell therapy
- cell fate