CD19-directed chimeric antigen receptor T cell therapy in Waldenström macroglobulinemia: a preclinical model and initial clinical experience.
M Lia PalombaDavid A QuallsSebastien MonetteShenon SethiAhmet DoganMikhail RoshalBrigitte SenechalXiuyan WangIsabelle RivièreMichel SadelainRenier J BrentjensJae H ParkEric L SmithPublished in: Journal for immunotherapy of cancer (2022)
This report summarizes preclinical and clinical activity of CD19-directed CAR T therapy in WM, demonstrating early tolerability and efficacy in patients with WM, and representing a possible treatment option in patients with heavily pretreated and relapsed or refractory WM. Larger studies evaluating CAR T therapy in WM are warranted, along with further evaluation into mechanisms of resistance to CAR T therapy.