Expression of PD-1/PD-L1 in head and neck squamous cell carcinoma and its clinical significance.
Shu-Wei ChenSi-Hao LiDing-Bo ShiWen-Mei JiangMing SongAn-Kui YangYu-Dong LiJin-Xin BeiWen-Kuan ChenQuan ZhangPublished in: The International journal of biological markers (2019)
The expression of PD-L1, PD-1, and P16 in HNSCC is significantly correlated. Human papillomavirus infection (P16 positive) is negatively related to postoperative recurrence. HNSCC patients with positive PD-L1/PD-1 expression tend to have better overall survival outcomes and lower probability of recurrence, providing more evidence for the PD-l-targeted immunotherapy of HNSCC.