Jagged1 promotes aromatase inhibitor resistance by modulating tumor-associated macrophage differentiation in breast cancer patients.

Hang LiuJingxuan WangMinghui ZhangQijia XuanZhipeng WangXin LianQingyuan Zhang

Published in: Breast cancer research and treatment (2017)

The Jagged1-Notch pathway showed elevated expression in AI-resistant breast cancer cells, resulting in macrophage differentiation towards M2 TAMs and there contributing to the acquisition of AI resistance.

Keyphrases

breast cancer cells
artificial intelligence
adipose tissue
poor prognosis
cell proliferation
signaling pathway
binding protein
deep learning