Jagged1 promotes aromatase inhibitor resistance by modulating tumor-associated macrophage differentiation in breast cancer patients.
Hang LiuJingxuan WangMinghui ZhangQijia XuanZhipeng WangXin LianQingyuan ZhangPublished in: Breast cancer research and treatment (2017)
The Jagged1-Notch pathway showed elevated expression in AI-resistant breast cancer cells, resulting in macrophage differentiation towards M2 TAMs and there contributing to the acquisition of AI resistance.