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Jagged1 promotes aromatase inhibitor resistance by modulating tumor-associated macrophage differentiation in breast cancer patients.

Hang LiuJingxuan WangMinghui ZhangQijia XuanZhipeng WangXin LianQingyuan Zhang
Published in: Breast cancer research and treatment (2017)
The Jagged1-Notch pathway showed elevated expression in AI-resistant breast cancer cells, resulting in macrophage differentiation towards M2 TAMs and there contributing to the acquisition of AI resistance.
Keyphrases
  • breast cancer cells
  • artificial intelligence
  • adipose tissue
  • poor prognosis
  • cell proliferation
  • signaling pathway
  • binding protein
  • deep learning