Lupus-associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated.

Chunmei WuQiong FuQiang GuoSheng ChenShyamal GoswamiShuhui SunTeng LiXingjian CaoFuying ChuZechuan ChenMei LiuYuanhua LiuTing FuPei HaoYi HaoNan ShenChunde BaoXiaoming Zhang

Published in: Annals of the rheumatic diseases (2019)

These findings demonstrated that mTORC1-overactivated lupus AtMs are abnormally differentiated with metabolic and functional dysregulations. Inhibiting mTORC1 signalling might be an attractive option to target AtMs and to improve therapeutic effectiveness in patients with lupus.

Keyphrases

systemic lupus erythematosus
disease activity
randomized controlled trial
rheumatoid arthritis
systematic review
signaling pathway
working memory