Quinolone-resistant Escherichia coli at the interface between humans, poultry and their shared environment- a potential public health risk.
Mabel Kamweli AworhJacob K P KwagaRene S HendriksenEmmanuel C OkolochaErin HarrellSiddhartha ThakurPublished in: One health outlook (2023)
PMQR genes were prevalent in E. coli isolates recovered from healthy humans, chickens and poultry farm/market environments. PMCR genes (mcr-1.1) occurred in PMQR-positive isolates recovered from manure and drinking water originating from poultry farm/market environments. It was found that the gene encoding ESBL coexisted with qnrS-positive isolates of human and avian origin. Horizontal transfer of PMQR genes among E. coli isolates in the human-poultry-environment interface has public health implications for the spread of antimicrobial resistance. Relevant government agencies should enforce regulations to restrict the use of critically important antimicrobials in poultry production.
Keyphrases
- antimicrobial resistance
- escherichia coli
- drinking water
- health risk
- genome wide
- public health
- endothelial cells
- genome wide identification
- genetic diversity
- heavy metals
- induced pluripotent stem cells
- health insurance
- bioinformatics analysis
- biofilm formation
- genome wide analysis
- health risk assessment
- pluripotent stem cells
- mental health
- copy number
- gene expression
- heat stress
- multidrug resistant
- staphylococcus aureus
- adverse drug