Comparative effectiveness and safety of intravenous methylprednisolone and tacrolimus monotherapy in ocular myasthenia gravis with unsatisfactory prednisone responses: a retrospective study.

Kai-Yue ZhangWei-Wei DuanYue-Bei LuoYi LiJue HuHuan Yang

Published in: Orphanet journal of rare diseases (2024)

Our findings suggest that both IVMP and tacrolimus monotherapy hold promise as viable treatment options for OMG patients with unsatisfactory responses to oral prednisone. The study supports the safety and effectiveness of both therapies, with IVMP exhibiting faster improvement and favourable efficacy in patients with high ocular QMG scores.

Keyphrases

myasthenia gravis
high dose
combination therapy
randomized controlled trial
open label
systematic review
optic nerve
low dose
deep learning