Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer.

Laura W Bowers Elaine M Glenny Arunima Punjala Nadia Atallah Lanman Audrey Goldbaum Caroline Himbert Stephanie A Montgomery Peiying Yang Jatin Roper Cornelia M Ulrich Andrew J Dannenberg Michael Francis Coleman Stephen D Hursting

Published in: Cancer prevention research (Philadelphia, Pa.) (2022)

Obesity is a colon cancer risk and/or progression factor, but the underlying mechanisms are incompletely understood. Herein we demonstrate that obesity enhances murine colon carcinogenesis and expression of numerous tumoral procancer and immunosuppressive pathways. Moreover, we establish that weight loss via LFD and/or the NSAID sulindac mitigate procancer effects of obesity.

Keyphrases

weight loss
bariatric surgery
roux en y gastric bypass
insulin resistance
metabolic syndrome
gastric bypass
weight gain
type diabetes
high fat diet induced
glycemic control
poor prognosis
gene expression
rna seq
adipose tissue
obese patients
skeletal muscle
genome wide
physical activity