Abnormal Intraepidermal Nerve Fiber Density in Disease: A Scoping Review.

S J Thomas Jonathan D EndersA KaiserL RovenstineL HeslopW HauserA ChadwickD E Wright

Published in: medRxiv : the preprint server for health sciences (2023)

Reduced IENFD occurs in a surprising number of human disease conditions. Abnormal IENFD contributes to important complications, including poor cutaneous vascularization, sensory dysfunction, and pain. Our analysis informs future rodent studies so they may better mirror human diseases impacted by reduced IENFD, highlights the breadth of diseases impacted by IENFD loss, and urges exploration of common mechanisms that lead to substantial IENFD loss as a complication in disease.

Keyphrases

endothelial cells
chronic pain
oxidative stress
pluripotent stem cells
pain management
risk factors
neuropathic pain
spinal cord
peripheral nerve
postoperative pain