Performance of clinical signs and symptoms, rapid and reference laboratory diagnostic tests for diagnosis of human African trypanosomiasis by passive screening in Guinea: a prospective diagnostic accuracy study.
Oumou CamaraMamadou CamaraLaura Cristina FalzonHamidou IlboudoJacques KaboréCharlie Franck Alfred CompaoréEric Maurice FèvrePhilippe BüscherBruno BuchetonVeerle LejonPublished in: Infectious diseases of poverty (2023)
Presence of swollen lymph nodes, important weight loss, severe itching or motor disorders are simple but accurate clinical criteria for HAT referral in HAT endemic areas in Guinea. Diagnostic performances of HAT Sero-K-Set and SD Bioline HAT are sufficient for referring positives to microscopy. Trypanolysis on DBS may discriminate HAT patients from false RDT positives. Trial registration The trial was registered under NCT03356665 in clinicaltrials.gov (November 29, 2017, retrospectively registered https://clinicaltrials.gov/ct2/show/NCT03356665 ).
Keyphrases
- lymph node
- weight loss
- end stage renal disease
- phase iii
- study protocol
- endothelial cells
- high resolution
- clinical trial
- newly diagnosed
- ejection fraction
- phase ii
- primary care
- prognostic factors
- peritoneal dialysis
- magnetic resonance imaging
- deep brain stimulation
- optical coherence tomography
- randomized controlled trial
- image quality
- contrast enhanced
- mass spectrometry
- body mass index
- early stage
- roux en y gastric bypass
- magnetic resonance
- skeletal muscle
- dual energy
- weight gain
- patient reported outcomes
- single cell