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Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection.

Saiaditya BadetiQingkui JiangAlireza NaghizadehHsiang-Chi TsengYuri BushkinSalvatore A E MarrasAnnuurun NisaSanjay TyagiFei ChenPeter RomanienkoGhassan YehiaDeborah EvansMoises Lopez-GonzalezDavid AllandRiccardo RussoWilliam GauseLanbo ShiDongfang Liu
Published in: Cell & bioscience (2022)
hCD147KI-NSG mice are more sensitive to COVID-19 infection compared to WT-NSG mice. The hCD147KI-NSG mouse model can serve as an additional animal model for further interrogation whether CD147 serve as an independent functional receptor or accessory receptor for SARS-CoV-2 entry and immune responses.
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