Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection.
Saiaditya BadetiQingkui JiangAlireza NaghizadehHsiang-Chi TsengYuri BushkinSalvatore A E MarrasAnnuurun NisaSanjay TyagiFei ChenPeter RomanienkoGhassan YehiaDeborah EvansMoises Lopez-GonzalezDavid AllandRiccardo RussoWilliam GauseLanbo ShiDongfang LiuPublished in: Cell & bioscience (2022)
hCD147KI-NSG mice are more sensitive to COVID-19 infection compared to WT-NSG mice. The hCD147KI-NSG mouse model can serve as an additional animal model for further interrogation whether CD147 serve as an independent functional receptor or accessory receptor for SARS-CoV-2 entry and immune responses.
Keyphrases
- sars cov
- mouse model
- immune response
- respiratory syndrome coronavirus
- high fat diet induced
- endothelial cells
- neoadjuvant chemotherapy
- nk cells
- induced pluripotent stem cells
- wild type
- pluripotent stem cells
- type diabetes
- binding protein
- radiation therapy
- dendritic cells
- adipose tissue
- coronavirus disease
- inflammatory response