Facile Synthesis of ZnMn2O4@rGO Microspheres for Ultrasensitive Electrochemical Detection of Hydrogen Peroxide from Human Breast Cancer Cells.
Yuanyuan LiKe HuanDongmei DengLi TangJinhua WangLiqiang LuoPublished in: ACS applied materials & interfaces (2020)
Mixed transition-metal oxides have witnessed increasing attention in catalysts and electrocatalysts. Herein, reduced graphene oxide-wrapped ZnMn2O4 microspheres (ZnMn2O4@rGO) were facilely synthesized through the solvothermal technique. The microstructure and morphology of ZnMn2O4@rGO microspheres were analyzed under Raman, X-ray photoelectron, X-ray diffraction, and energy-dispersive spectroscopies and scanning electron microscopy. The synthesized ZnMn2O4@rGO was employed as an excellent electrocatalyst for the reduction of hydrogen peroxide (H2O2). The ZnMn2O4@rGO-modified glassy carbon electrode (ZnMn2O4@rGO/GCE) exhibited a linear detection to H2O2 in a wide concentration range of 0.03-6000 μM with a detection limit of 0.012 μM. The biosensor was evaluated to determine H2O2 secreted by human breast cancer cells (MCF-7), indicating its promising applications in physiology and diagnosis.
Keyphrases
- reduced graphene oxide
- hydrogen peroxide
- gold nanoparticles
- electron microscopy
- label free
- breast cancer cells
- endothelial cells
- nitric oxide
- transition metal
- molecularly imprinted
- high resolution
- loop mediated isothermal amplification
- real time pcr
- solid phase extraction
- pluripotent stem cells
- ionic liquid
- induced pluripotent stem cells
- quantum dots
- magnetic resonance imaging
- magnetic resonance
- working memory
- white matter
- multiple sclerosis
- gas chromatography mass spectrometry
- mass spectrometry