Phase Ib/II Study of Lacnotuzumab in Combination with Spartalizumab in Patients with Advanced Malignancies.
Jibran AhmedBettzy StephenYali YangEvan KwiatkowskiChinenye Lynette EjezieShubham PantPublished in: Journal of immunotherapy and precision oncology (2024)
The study completed phase Ib dose escalation and phase II. However, gating criteria for efficacy were not met for expansion beyond 80 patients in phase II and the sponsor did not continue development of the combination of spartalizumab and lacnotuzumab for oncology indications. The potential signal of activity in pancreatic cancer should be further explored.