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Interrupting an IFN-γ-dependent feedback loop in the syndrome of pyogenic arthritis with pyoderma gangrenosum and acne.

Wonyong LeeDeborah L StonePatrycja HoffmannSofia RosenzweigWanxia Li TsaiMassimo GadinaTina RomeoChyi-Chia Richard LeeDavide RandazzoPallavi Pimpale ChavanKalpana ManthiramScott W CannaYong Hwan ParkAmanda K OmbrelloIvona AksentijevichDaniel L KastnerJae Jin Chae
Published in: Annals of the rheumatic diseases (2024)
mutations trigger a pyrin-IL-18-IFN-γ positive feedback loop that drives PAPA disease activity and is a target for JAK inhibition.
Keyphrases
  • disease activity
  • rheumatoid arthritis
  • systemic lupus erythematosus
  • rheumatoid arthritis patients
  • dendritic cells
  • ankylosing spondylitis
  • immune response
  • transcription factor
  • juvenile idiopathic arthritis