Interrupting an IFN-γ-dependent feedback loop in the syndrome of pyogenic arthritis with pyoderma gangrenosum and acne.
Wonyong LeeDeborah L StonePatrycja HoffmannSofia RosenzweigWanxia Li TsaiMassimo GadinaTina RomeoChyi-Chia Richard LeeDavide RandazzoPallavi Pimpale ChavanKalpana ManthiramScott W CannaYong Hwan ParkAmanda K OmbrelloIvona AksentijevichDaniel L KastnerJae Jin ChaePublished in: Annals of the rheumatic diseases (2024)
mutations trigger a pyrin-IL-18-IFN-γ positive feedback loop that drives PAPA disease activity and is a target for JAK inhibition.