The role of early natural killer cell adoptive infusion before engraftment in protecting against human herpesvirus-6B encephalitis after naïve T-cell-depleted allogeneic stem cell transplantation.

Mercedes GasiorCristina FerrerasRaquel de PazDavid BuenoYasmina MozoLuisa SisinniJuan Torres CanizalesBerta GonzálezRaquel Olivas-MazónAntonio MarcosAna Belén RomeroAída ConstanzoIsabel MironesAlba Fernández-ArroyoAntonio BalasJose Luis VicarioAdela EscuderoVíctor Jiménez YustePérez-Martínez Antonio

Published in: Transfusion (2021)

In this clinical study, we show that early adoptive NK cell infusion after a 45RA+ TCD allo-HSCT graft is safe and can prevent HHV-6B encephalitis. We recommend infusing adoptive NK cells after allo-HSCT using CD45RA+ TCD grafts.

Keyphrases

nk cells
stem cell transplantation
cell therapy
hematopoietic stem cell
high dose
low dose
rheumatoid arthritis
stem cells
endothelial cells
mesenchymal stem cells
disease activity
single cell
bone marrow
systemic lupus erythematosus
ankylosing spondylitis
clinical trial
pluripotent stem cells