A review on various analytical methods for the estimation of olanzapine - An antipsychotic drug.

Olanzapine (OLZ) is an antipsychotic agent which is thienobenzodiazepine derivative. It is used either in combination with other drugs like Carbamazepine, Simvastatin, Clozapine etc. or as a single drug. The present work is mainly focused on various approaches for the analysis of OLZ in bulk drugs as well as their pharmaceutical formulations. It is also focused on various bioanalytical methods used for the analysis. Based on our survey, it is observed that many analytical techniques were carried out using UV-Spectrophotometry, Mass spectrophotometry, LC-MS/MS techniques, and chromatographic techniques like HPLC, and HPTLC in both bulk and solid dosage forms. Bioanalytical techniques are also performed using human plasma or serum etc., The analysis was carried out either for the single drug or for a combination of drugs. The review depicts the rate usage of the different methodologies for the analysis of OLZ. A measurable amount of information is gathered and utilized for the strategies.