Effect of nintedanib in patients with systemic sclerosis-associated interstitial lung disease and risk factors for rapid progression.
Zsuzsanna H McMahanToby M MaherElizabeth R VolkmannYannick AllanoreVanessa SmithShervin AssassiYong-Bum ParkAnna-Maria Hoffmann-VoldMasataka KuwanaChristian StockMargarida AlvesSteven SambevskiChristopher P DentonPublished in: RMD open (2023)
In the SENSCIS trial, subjects with SSc-ILD who had early SSc, elevated inflammatory markers or extensive skin fibrosis had a more rapid decline in FVC over 52 weeks than the overall trial population. Nintedanib had a numerically greater effect in patients with these risk factors for rapid ILD progression.