Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses.
Rafik DeyMelanie A FolkinsNicholas J AshboltPublished in: NPJ biofilms and microbiomes (2021)
Human respiratory syncytial virus (RSV) is a major cause of acute respiratory tract infections in children and immunocompromised adults worldwide. Here we report that amoebae-release respirable-sized vesicles containing high concentrations of infectious RSV that persisted for the duration of the experiment. Given the ubiquity of amoebae in moist environments, our results suggest that extracellular amoebal-vesicles could contribute to the environmental persistence of respiratory viruses, including potential resistance to disinfection processes and thereby offering novel pathways for viral dissemination and transmission.
Keyphrases
- respiratory tract
- respiratory syncytial virus
- human health
- respiratory failure
- endothelial cells
- sars cov
- drinking water
- induced pluripotent stem cells
- genetic diversity
- intensive care unit
- hepatitis b virus
- pluripotent stem cells
- extracorporeal membrane oxygenation
- aortic dissection
- acute respiratory distress syndrome