Identification of IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study.
Antonio JuliàFrancisco BlancoBenjamín Fernández-GutierrezAntonio GonzálezJuan D CañeteJoan MaymóMercedes Alperi-LópezAlex OlivèHéctor CorominasVíctor Martínez-TaboadaIsidoro González-ÁlvaroAntonio Fernandez-NebroAlba ErraSimón Sánchez-FernándezArnald AlonsoMaría López-LasantaRaül TortosaLaia CodóJosep Lluis GelpiAndrés C García-MonteroJaume BertranpetitDevin AbsherRichard M MyersJesús TorneroSara MarsalPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2017)
To our knowledge, this is the first GWAS of RF positivity in RA. Variation at the IRX1 locus on chromosome 5p15.3 is associated with the presence of RF. Our findings indicate that IRX1 and HLA-DRB1 are the strongest genetic factors for RF production in RA.