Umbilical cord gene expression reveals the molecular architecture of the fetal inflammatory response in extremely preterm newborns.
Daniel CostaRobert CasteloPublished in: Pediatric research (2015)
The FIR expression signature in UC tissue contains molecular clues about signaling pathways that trigger FIR, and it is consistent with an acute inflammatory response by fetal innate and adaptive immune systems, which participate in the pathogenesis of neonatal brain damage.
Keyphrases
- inflammatory response
- umbilical cord
- gene expression
- mesenchymal stem cells
- lipopolysaccharide induced
- lps induced
- toll like receptor
- low birth weight
- immune response
- poor prognosis
- gestational age
- liver failure
- signaling pathway
- dna methylation
- pregnant women
- oxidative stress
- single molecule
- respiratory failure
- preterm infants
- preterm birth
- bone marrow
- epithelial mesenchymal transition
- aortic dissection
- cord blood
- binding protein
- brain injury
- intensive care unit
- multiple sclerosis
- extracorporeal membrane oxygenation
- endoplasmic reticulum stress