Dysregulation of Components of the Inflammasome Machinery After Bariatric Surgery: Novel Targets for a Chronic Disease.
Vicente Herrero-AguayoPrudencio Sáez-MartínezJuan L López-CánovasJuan J Prados-CarmonaMaría D Alcántara-LagunaFernando L LópezMaría J Molina-PuertaAlfonso Calañas-ContinenteAntonio MembrivesJuan CastillaJuan Ruiz-RaveloRosario Alonso-EchagueElena M Yubero-SerranoJusto P CastañoManuel D GaheteMaría A Gálvez-MorenoRaul Miguel LuqueAura Dulcinea Herrera-MartínezPublished in: The Journal of clinical endocrinology and metabolism (2021)
Bariatric surgery induces a profound alteration in the gene expression pattern of components of the inflammasome machinery in PBMCs. Expression and changes of certain inflammasome components are associated to baseline metabolic comorbidities, including type 2 diabetes, and may be related to the improvement and reversion of some obesity-related comorbidities after bariatric surgery.