A genomic perspective on the near-term impact of doxycycline post-exposure prophylaxis on Neisseria gonorrhoeae antimicrobial resistance.

Tatum D Mortimer Yonatan Hagai Grad

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)

Pre-existing tetracycline resistance in Neisseria gonorrhoeae limits the effectiveness of post-exposure prophylaxis (PEP) with doxycycline against gonorrhea, and selection for tetracycline resistance may influence prevalence of multi-drug resistant strains. Using genomic and antimicrobial susceptibility data from N. gonorrhoeae, we assessed the near-term impact of doxycycline PEP on N. gonorrhoeae resistance.

Keyphrases

drug resistant
antimicrobial resistance
multidrug resistant
acinetobacter baumannii
preterm infants
randomized controlled trial
copy number
systematic review
escherichia coli
dna methylation
gestational age
gene expression
preterm birth
cystic fibrosis