Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach.
Courtney R SchottAmanda L KoehneLeanne C SaylesElizabeth P YoungCuyler LuckKatherine YuAlex G LeeMarcus R BreeseStanley G LeungHang XuAvanthi Tayi ShahHeng-Yi LiuAviv SpillingerInge H BehroozfardKieren D MariniPhuong T DinhMaría V Pons VenturaEmma N VanderboonFlorette K HazardSoo-Jin ChoRaffi S AvedianDavid G MohlerMelissa N ZimelRosanna L WustrackChristina CurtisMarina SirotaE Alejandro Sweet-CorderoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
The variation in metastasis predilection sites between osteosarcoma PDX-derived cell lines demonstrates their ability to recapitulate the spectrum of the disease observed in patients. We describe here a panel of new osteosarcoma PDX-derived cell lines that we believe will be of wide use to the osteosarcoma research community.