Pragmaticism of Randomized Controlled Trials of Biologic Treatment With Methotrexate in Rheumatoid Arthritis: A Systematic Review.
May Yee ChoiCheryl C M BarnabeClaire E BarberVivian BykerkJanet E PopeGlen S HazlewoodPublished in: Arthritis care & research (2019)
RCTs of biologic DMARD treatment in combination with methotrexate for RA were rated as predominantly explanatory, which may affect the generalizability of trial results to clinical practice.