A pilot randomized clinical trial of cryopreserved versus liquid-stored platelet transfusion for bleeding in cardiac surgery: The cryopreserved versus liquid platelet-New Zealand pilot trial.
Shay P McGuinnessRichard CharlewoodEileen GilderRachael ParkeKatia HayesSarah L MorleyAous Al-IbousiRenae DeansBelinda HoweLacey JohnsonDenese C MarksMichael Charles Readenull nullnull nullPublished in: Vox sanguinis (2021)
This pilot randomized controlled trial demonstrated the feasibility of the protocol and adds to accumulating data supporting the safety of this intervention. Given the clear advantage of prolonged shelf-life, particularly for regional hospitals in New Zealand, a definitive non-inferiority phase III trial is warranted.
Keyphrases
- phase iii
- randomized controlled trial
- clinical trial
- study protocol
- cardiac surgery
- open label
- phase ii
- double blind
- placebo controlled
- acute kidney injury
- ionic liquid
- healthcare
- umbilical cord
- electronic health record
- cord blood
- atrial fibrillation
- systematic review
- radiation therapy
- room temperature
- machine learning