Low oxygen tension increases mitochondrial membrane potential and enhances expression of antioxidant genes and implantation protein of mouse blastocyst cultured in vitro.
Yun-Yi MaHuei-Wen ChenChii-Ruey TzengPublished in: Journal of ovarian research (2017)
Low O2 tension may improve embryo viability by increasing expression of antioxidant enzymes and glucose transporter activities. It provides an environment conducive to viability by upregulation of LIFR/VEGF and increased MtMP which could enhance implantation potential and reduce apoptosis in mouse blastocyst. These effects may be initiated and regulated by HIF-2α, a key mediator in a hypoxic environment.
Keyphrases
- oxidative stress
- poor prognosis
- endothelial cells
- binding protein
- anti inflammatory
- long non coding rna
- cell proliferation
- endoplasmic reticulum stress
- vascular endothelial growth factor
- cell death
- blood glucose
- genome wide
- type diabetes
- signaling pathway
- metabolic syndrome
- gene expression
- risk assessment
- insulin resistance
- skeletal muscle
- glycemic control