Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly.

Jay ChauhanWenbo YuSteven CardinaleTimothy J OppermanAlexander D MacKerellSteven FletcherErik Ph de Leeuw

Published in: Drug design, development and therapy (2020)

We identify optimized small molecule benzothiazole indolene scaffolds that bind to Lipid II for further development as antibacterial therapeutics.

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