Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis.

Doudou LiYing LuShuai YuanXiaxia CaiYuan HeTherese HeskethQiong WuDi HeAiping FangYacong BoPeige SongDebby BogaertKostas TsilidisSusanna C LarssonHuanling YuHuilian ZhuEvropi TheodoratouYimin ZhuXue Li

Published in: The American journal of clinical nutrition (2022)

TMAO might be a novel biomarker related to human health conditions including all-cause mortality, hypertension, CVD, DM, cancer, and kidney function. Further studies are needed to investigate whether circulating TMAO concentrations could be an intervention target for chronic disease.This review was registered at www.crd.york.ac.uk/prospero/ as CRD42021284730.

Keyphrases

human health
systematic review
risk assessment
meta analyses
case control
blood pressure
randomized controlled trial
climate change
papillary thyroid
squamous cell carcinoma
squamous cell
type diabetes
insulin resistance
weight loss
glycemic control